Nikola Jokic has his most career points per game against the Pacers, with 25.5 per game.

nikola jokic highest career ppg by opponent

OPP	PPG	GP	MPG	RPG	APG	SPG	BPG	TPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	MIN	PTS	REB	AST	STL	BLK	TOV	PF	+/-
Pacers	25.5	15	32.0	9.9	5.9	1.9	0.7	3.1	9.9	16.9	58.7	1.4	3.1	45.7	4.2	5.0	84.0	480	382	148	89	29	11	47	44	+65
Spurs	24.4	31	32.6	9.9	7.6	1.0	0.7	3.7	10.0	16.5	60.4	1.5	3.2	45.9	3.0	3.5	84.5	1,010	756	307	236	32	22	116	87	+113
Wizards	23.4	17	31.0	11.8	6.6	1.4	0.6	2.8	8.9	13.8	64.3	1.2	2.2	54.1	4.4	5.2	84.3	528	397	200	112	24	11	47	40	+134
Nets	23.2	18	30.5	11.7	6.6	1.4	0.8	2.0	8.8	14.9	59.3	0.9	2.7	33.3	4.7	5.3	88.4	549	418	211	118	26	15	36	62	+145
Knicks	23.1	17	30.5	10.5	6.1	0.6	0.6	2.7	9.1	16.0	57.0	1.2	3.1	40.4	3.6	4.6	78.2	518	392	178	103	11	11	46	34	+130
Celtics	22.8	17	31.7	10.5	6.9	1.2	0.8	2.9	8.7	15.5	56.3	1.3	3.5	37.3	4.1	4.8	85.4	538	388	179	117	21	14	49	42	+30
76ers	22.8	16	33.6	11.4	7.4	0.9	0.9	2.9	8.1	15.0	54.2	0.9	2.6	34.1	5.6	7.1	78.9	537	364	182	119	14	15	47	37	+90
Pelicans	22.5	29	30.5	10.4	7.8	1.2	0.8	2.9	8.9	15.0	59.2	1.3	3.5	38.2	3.4	4.1	83.1	886	653	303	226	36	24	83	75	+143
Bucks	22.1	16	31.9	10.1	8.7	1.1	0.7	3.1	8.8	16.7	52.8	1.7	4.2	40.3	2.8	3.4	83.3	511	354	161	139	18	11	49	29	+52
Timberwolves	21.9	34	32.4	10.7	6.5	1.0	0.7	3.4	8.6	15.9	53.9	0.9	3.1	28.3	3.9	4.9	79.5	1,102	746	364	222	35	24	116	118	+156
Clippers	21.6	30	31.2	11.4	6.5	1.1	0.7	2.7	7.8	15.3	51.3	1.1	3.4	32.4	4.9	5.8	84.4	936	649	343	194	32	20	82	86	+101
Hornets	21.3	18	32.0	13.5	7.2	0.9	0.7	3.3	8.3	15.7	52.7	0.7	2.4	27.9	4.1	5.1	80.4	576	384	243	129	17	12	59	50	+172
Thunder	21.3	31	31.9	10.5	6.7	1.0	0.8	3.1	8.1	14.1	57.3	0.9	3.2	29.6	4.2	4.7	87.8	989	660	326	209	31	25	95	88	+173
Suns	20.8	27	32.6	10.8	6.9	1.4	0.7	2.9	7.6	13.6	56.0	1.0	2.7	38.9	4.5	5.3	84.0	881	561	291	186	37	19	79	81	+215
Rockets	20.7	30	28.7	11.2	6.9	1.1	0.7	3.4	8.2	14.8	55.2	0.7	2.0	35.6	3.7	4.7	79.3	860	622	335	208	34	21	103	90	+76
Raptors	20.6	18	30.6	11.5	6.3	0.9	0.8	2.4	8.1	13.5	60.1	0.6	1.9	31.4	3.7	4.3	87.0	550	370	207	113	17	15	44	31	+70
Trail Blazers	20.4	32	30.5	10.0	6.8	1.0	0.8	2.5	8.0	14.0	57.0	1.1	3.0	37.1	3.3	4.0	82.7	975	653	320	217	31	25	80	90	+209
Lakers	20.2	27	31.2	10.4	6.5	1.3	0.8	3.0	7.5	14.1	53.1	0.9	3.0	30.9	4.2	4.8	87.7	843	545	280	176	34	21	81	70	+172
Grizzlies	20.1	30	31.7	10.8	5.8	1.5	0.6	3.1	7.6	12.9	59.2	1.0	2.7	37.8	3.8	4.5	84.3	950	602	323	175	44	18	94	88	+207
Warriors	19.7	30	30.6	10.7	7.0	1.6	0.6	3.4	7.2	14.1	51.2	0.5	2.4	20.5	4.7	5.8	81.6	919	591	321	211	47	17	102	68	0
Pistons	19.6	17	29.3	8.8	6.8	1.4	1.1	2.1	7.8	13.6	57.3	0.6	2.2	26.3	3.4	4.2	81.7	498	334	149	116	24	19	35	45	+82
Heat	19.6	18	33.2	11.2	6.3	1.1	0.7	2.4	7.7	14.1	54.7	1.0	2.4	40.9	3.2	3.8	82.6	597	353	202	113	20	13	44	52	+142
Jazz	19.5	32	30.8	10.2	7.2	1.3	0.8	2.8	7.4	13.3	55.9	1.0	2.7	35.6	3.7	4.5	81.3	986	624	325	230	40	24	88	101	+24
Kings	19.5	29	31.7	10.8	7.4	1.2	0.8	2.6	7.4	13.8	53.9	0.9	3.0	28.7	3.8	4.5	84.6	920	565	312	214	36	22	75	84	+164
Magic	19.1	17	32.5	10.1	8.5	1.6	0.7	2.5	7.4	14.1	52.5	1.1	3.2	34.5	3.1	3.8	81.5	552	324	171	145	27	12	43	44	+163